NRAS p.Q61L Reference Standard
CBP10311
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| Introduction | |
| Format | Genomic DNA |
| Description | NRAS Q61L is a hotsopt mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61L confers a loss of function on Nras protein as indicated by increase Erk and Mek phosphorylation, and activation of Ck2alpha in cell culture (PMID: 27251789). |
| Technical Data | |
| DNA Change | c.182A>T |
| AA Change | p.Q61L |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000369535 |
| Cosmic ID | COSM583 |
| Chr position(GRCh37) | chr1:115256529 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
