PIK3CA p.E545G Reference Standard
CBP10543
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| Introduction | |
| Format | Genomic DNA |
| Description | PIK3CA E545G is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E545G confers a gain of function on the Pik3ca protein as demonstrated by increased phosphorylation of Akt and transFormation in cell culture (PMID: 17376864, PMID: 29533785). |
| Technical Data | |
| DNA Change: | c.1634A>G |
| AA Change | p.E545G |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50% |
| Transcript | NM_006218 |
| Cosmic ID | COSM764 |
| Chr position(GRCh37) | chr3:178936092 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 2-8°C |
| Expiry | 36 months from the date of manufacture |
