hCD19/A20
CBPG0076
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| I. Background | |
| CD19（Cluster of Differentiation 19）是一种跨膜糖蛋白，属于免疫球蛋白超家族成员， 主要表达于 B 淋巴细胞谱系细胞表面，包括前 B 细胞、成熟 B 细胞及大多数 B 细胞恶性肿 瘤细胞。其功能是作为 B 细胞受体（BCR）复合物的共受体，参与 B 细胞活化、增殖和分 化信号的传导。CD19 作为 B 细胞恶性肿瘤的核心靶点，有助于了 CAR-T 等精准免疫治疗的 开展，显著改善了患者预后。 | |
| II. Introduction | |
| Host Cell: | A20 |
| Expressed gene: | hCD19 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+0.05 mM 2-mercaptoethanol+1 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | B lymphocyte |
| Morphology: | lymphoblast |
| Growth Properties: | suspension |
| IV. Representative Data | |
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Figure 1. Recombinant hCD19/A20 stably expressing CD19. |
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