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    kdpay钱包(中国) /药靶模型 /GPCR靶点细胞 /Class A(Rhodopsin) /CCR1/CHO

    CCR1/CHO

    CBP71353

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    I. Background

    C-C chemokine receptor type 1 (CCR1) is a G protein-coupled receptor member of the CC chemokine subfamily of
    receptors. Following interaction with its specific chemokine ligands, like macrophage inflammatory protein 1 alpha
    (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), and monocyte
    chemoattractant protein 3 (MCP-3), it triggers the onset of a process known as chemotaxis. 

     
    II. Introduction
    Host Cell:

    CHO

    Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
    Freeze Medium: 90% FBS+10% DMSO
    Culture Medium: F12K+10%FBS+5μg/ml Puromycin
    Mycoplasma Status: Negative
    Storage: Liquid nitrogen immediately upon delivery
    Application(s):

    Functional assay for CCR1

    Transducer: Gi
     
    Ⅲ. Description of Host Cell Line
    Organism: Hamster
    Tissue: Ovary
    Morphology: Epithelial
    Growth Properties: Adherent
     
    Ⅳ. Representative Data

    Figure 1. Recombinant CCR1/CHO constitutively expressing CCR1.

    Figure 2. CCL3 effect on CHO-K1-CCR1 clone 6.


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